Webpartial sequence of trowaglerix α subunit, a potent specific GPVI-targeting snaclec (snake venom C-type lectin protein). Hexapeptide (Tro6 [trowaglerix a chain hexapeptide, CKWMNV]) and decapeptide (Troα 10) derived from trowaglerix α specifically inhibited collagen-induced platelet aggregation through blocking platelet GPVI receptor. WebJun 10, 2024 · The researchers, therefore, designed a drug to interact with the protein glycoprotein VI. They used trowaglerix, a protein in the venom of the Tropidolaemus wagleri snake, to block GPVI activity. An earlier study by the team found that trowaglerix worked through GPVI antagonism.
Snake venom might provide a safer antiplatele EurekAlert!
WebJun 12, 2024 · Previous research has found that trowaglerix, a protein in the venom of the Tropidolaemus waglerix snake, stimulated platelets to form blood clots by latching onto GPVI. Platelets missing GPVI do not form blood clots inpatients and … WebJun 8, 2024 · Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet. 1 Europe PMC … new eso armor sets
Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent …
WebTrowaglerix activates platelets through specific binding to GPVI, leading to kinases-dependent exposure of functional a IIbb 3 and platelet aggregation, and also induces … WebApr 1, 2008 · trowaglerix Introduction Platelet adhesion and aggregation on damaged vessel walls play important roles in hemostasis and thrombosis. The matrix protein collagen in … WebTrowaglerix induced platelet aggregation of washed human platelets and platelet-rich plasma (PRP) in a concentration-dependent manner. Biotinylated trowaglerix specifically … interpreting ihc stains