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WebJan 31, 2024 · Background: Bile duct ligation (BDL) has been used for experimental research on hepatic encephalopathy (HE) caused by chronic liver disease. However, little research has been done on a BDL model in C57BL/6 mouse. Therefore, we evaluated the suitability of a BDL model in C57BL/6 mouse for the study of HE and determined which behavioral tests … WebBDL is a severe model of extrahepatic cholestasis due to the complete interruption of bile flow. Increases in the canalicular genes such as Mdr, Mrp2, or Bsep after BDL likely reflect a general adaptation to liver injury since enhanced efflux transporter function cannot restore bile flow in BDL animals. dialysis ottumwa
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