Gata3 and breast cancer

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August undefined, 2024

WebApr 8, 2024 · Breast cancer is a heterogeneous disease with different molecular subtypes. Breast cancer is the second leading cause of mortality in woman due to rapid metastasis and disease recurrence. Precision medicine remains an essential source to lower the off-target toxicities of chemotherapeutic agents and maximize the patient benefits. This is a … WebThe GATA3 expression was closely associated with tumor size as well as metastasis. GATA3 significantly suppressed OS cells proliferation, migration and invasion. EMT-associated transcript factor, slug, was transcriptionally inhibited by GATA3, thereby regulation of EMT in OS.Conclusion: GATA3 serves as a tumor suppressor in OS and …

GATA3 - Wikipedia

WebJan 1, 2015 · GATA3 is a highly conserved, essential transcription factor expressed in a number of tissues, including the mammary gland. GATA3 expression is required for normal development of the mammary gland where it is estimated to be the most abundant transcription factor in luminal epithelial cells. In breast cancer, GATA3 expression is … WebThis real-world cohort analysis assessed the efficacy of alpelisib and endocrine treatment (ET) combinations in a post-everolimus setting. Thirteen women who started alpelisib … getting rid of gout crystals

Role of GATA3 exon 6 germline mutations in breast cancer progression …

Web21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the … WebNov 12, 2024 · GATA3 has been shown to be associated with the luminal subtype of breast cancer, whereas 88% of estrogen receptor (ER)-negative tumors retained GATA3 … WebThis real-world cohort analysis assessed the efficacy of alpelisib and endocrine treatment (ET) combinations in a post-everolimus setting. Thirteen women who started alpelisib and ET at standard doses between 2024 and 2024 for advanced breast cancer (ABC), after undergoing CDK4/6i and everolimus treatment, were eligible for the study entry. The … christopher heitland md

The significance of GATA3 expression in breast cancer: a 10-year …

What does GATA3 positive mean? - Studybuff

WebStudies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding … WebJan 28, 2024 · GATA3 is known to be one of the most frequently mutated genes in breast cancer. More than 10% of breast tumors carry mutations in this gene. However, the … getting rid of gray hair permanentlyWebNov 20, 2014 · GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in … christopher hekimian

"WebWe performed a survival analysis of 989 breast cancer patients from The Cancer Genome Atlas (TCGA), and validated the findings in 202 breast cancer patients from tissue … " - Gata3 and breast cancer

Gata3 and breast cancer

GATA3 inhibits breast cancer growth and pulmonary …

WebGATA3 is a member of a family of zinc-finger transcription factors present in vertebrate organisms and involved in the differentiation of breast epithelia, urothelia, and a subset … WebDec 15, 2005 · GATA binding protein 3 (GATA3), a transcriptional activator, emerged as one of the top genes with low expression in the meta-signature. In breast cancer, high GATA3 mRNA levels are seen in the luminal A …

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Web14 GATA3 expression seems to be more extensive in lower grade tumors and positive cases, and cases with high expression may have a better survival 14,15 However, none of those studies have assessed the specificity of GATA3 for breast cancer. In another study, strong expression of GATA3 (in >50% tumor cells) was detected only in mammary (94% ... WebNational Center for Biotechnology Information

WebSep 17, 2024 · GATA3 mutations are known to play an important role in breast cancer progression. The exact role and mechanisms of these mutations remain controversial as some studies suggest a relation to breast tumor growth, while others suggest a relation to longer survival. GATA3 germline mutations are not well studied in breast cancer. WebJan 24, 2024 · GATA3 is a sensitive biomarker for carcinomas of breast and urothelial origins, however its expression is not specific. • GATA3 expression is found in a relatively small but significant proportion of primary non-small cell lung carcinoma (NSCLCs), especially lung squamous cell carcinoma, which can potentially lead to a misdiagnosis of …

WebFeb 6, 2024 · GATA3 is also targeted and inhibited by miR-720, an anti-oncogenic miRNA downregulated in TAMs from metastatic breast cancer patients. The restoration of miR-720 expression in M2-macrophages drastically reduces the production of anti-inflammatory cytokines and the ability of macrophages to stimulate BC cell migration [ 56 ]. WebGATA3 can be particularly useful as a marker for metastatic breast carcinoma, especially triple-negative and metaplastic carcinomas, which lack specific markers …

WebTriple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. ...

christopher hejlWebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four qualified genes, ERBB2, GATA3, AGR2, and ANXA1. Their expression pattern was validated by RT-PCR in both breast cell lines and tissue samples. Loss of ANXA1 in breast cancer was ... christopher heitzman rockaway njWebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four … getting rid of google pop up adsWebJul 1, 2024 · TRPS1, GATA3, and SOX10 expression (x10) in representative cases of triple-negative invasive breast carcinoma of no special type (IBC-NST). Case 1 shows a triple-negative IBC-NST with high expression of TRPS1 and GATA3 and negative expression of … christopher helaliWebMar 13, 2024 · GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their... getting rid of gray hairWebGATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). [29] Studies in mice indicate that the gene is critical for the normal development of … getting rid of gophers permanentlyWebNov 12, 2024 · GATA3 has been shown to be associated with the luminal subtype of breast cancer, whereas 88% of estrogen receptor (ER)-negative tumors retained GATA3 expression [ 15 ]. Its expression rate in triple-negative cancer ranged from 20.16 to 48% [ 16, 17] in contrast to 74.6% in apocrine type triple-negative breast cancer [ 18 ]. getting rid of gopher