Diabetogenic action
WebAlloxan has an interesting diabetogenic action which appears to be associated with removal of essential zinc from insulin by chelation. Such permanent diabetes may be induced in fish, dogs, cats, sheep, some birds, monkeys and other creatures, but not in man, owls or guinea-pigs; certain pyrimidines related to alloxan show some such activity. WebMar 4, 2024 · The underlying diabetogenic action of statins likely results from a complex interplay between pancreatic and extrapancreatic effects. Nevertheless, cardiovascular protection by statin treatment outweighs the risks associated with development of new-onset diabetes or modest deterioration of glucose control in individuals with diabetes [ 3 ].
Diabetogenic action
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WebDec 18, 2007 · Both alloxan and streptozotocin induce insulin deficiency. While the mechanisms of beta cell-selective action through uptake via the GLUT2 glucose transporter and beta cell death via necrosis are identical, ROS in the case of alloxan and DNA alkylation in the case of streptozotocin mediate the toxic action of these glucose analogues (Fig. 4 ). WebMay 8, 2024 · Direct Metabolic Functions: GH is anabolic. It stimulates the growth of almost all tissues of the body that are capable of growing (increase in the number of cells). GH also increases the rate of protein synthesis in most cells of the body and decreases the rate of glucose utilization throughout the body (diabetogenic action).
WebJan 25, 2016 · Diabetogenic action of STZ differs among species, strain, gender and age of animal. Factors that contribute to these differences possibly involve cellular mechanisms such as β-cell deficiency and repair, which are under genetic control [132]. Researchers have successfully used mice, rats, monkeys, guinea pigs, hamsters, dogs and cats for … WebApr 12, 2024 · In addition, to a certain extent, blood TMPP and TPHP share the most common biomolecular intermediators and pathways. In contrast, urinary DBP and DPHP have relatively unique molecular characteristics, suggesting differential modes of action and diabetogenic potentials, which are perhaps caused by their different chemical structures.
WebCotes and coworkers described the diabetogenic action of pure anterior pituitary growth hormone in cats.In intact adult dogs and cats the repeated administration of growth hormone induces an intensively diabetic condition with all symptoms of diabetes including severe ketonuria and ketonemia. WebDec 15, 2015 · Figure 2: Potential sites of action of statins on β-cell function identified from in vitro studies. ( 1) Statins reduce mRNA and protein expression of GLUT2, limiting glucose uptake. ( 2) Statins...
WebWe have examined the diabetogenic action of authentic biosynthetic hGH on whole body glucose disposal, hepatic glucose output, and glucose metabolism in individual …
WebDec 19, 2024 · Type 1 diabetes is an autoimmune disease where the pancreas does not produce any insulin and the person with diabetes takes insulin injections to regulate blood glucose levels. In Type 2 diabetes the pancreas produces too little insulin or the body rejects the insulin being produced. city cuts youngsville laWebdiabetogenic in British English (ˌdaɪəˌbiːtəˈdʒɛnɪk, ˌdaɪəˌbɛtəˈdʒɛnɪk) adjective. medicine. causing or producing diabetes. Collins English Dictionary. What is an antagonist to … citycutting com auWeb“Thanks, I hate it.” Yeah. That needs saying. Thank you Renza Scibilia. I don’t need to be told in general how hard diabetes can be. Or scary. Or… city cuts silver city nmWebThe diabetogenic action of STZ in laboratory animals was discovered during early testing of this natural product for anticancer activity (Rakieten et al. 1963). It … dictionary profligateWebAug 24, 2024 · In humans and NOD mouse, the combined action of many MHC alleles with the non-MHC genes results in their diabetogenic action [ 28, 63 ]. The BB rats are the most valuable experimental animals for studying the genetic basis of type 1 diabetes [ 64] and also in intervention studies [ 65, 66 ]. city cutz orilliaWebInsulin action was more substantially reduced in muscles (∼ 50%) than in adipose tissues (∼ 20%). These studies confirm that the diabetogenic action of hGH in the rat is due to a combination of inhibition of insulin suppression of hepatic glucose output and inhibition of the uptake and subsequent utilization of glucose in skeletal muscles. dictionary professionalWebjunod, a, diabetogenic action of streptozotocin - relationship of dose to metabolic response, journal of clinical investigation 48: 2129 (1969). google scholar. junod, a, studies of diabetogenic action of streptozotocin, proceedings of the society for experimental biology and medicine 126: 201 (1967). dictionary professor