Circhif1a

Author: imhp

August undefined, 2024

WebIn BC, sEVs derived from hypoxic CAFs show higher circHIF1A levels than normoxic CAFs. circHIF1A acts as a sponge for miR-580-5p, lowering its levels, whilst miR-580-5p targets the CD44 molecule mRNA, decreasing CD44 expression . Protein transfer from CAFs to cancer cells through sEVs also plays an essential role in tumorigenesis. Breast ... WebThe discovery may establish circHIF1A as a therapeutic target in breast cancer treatment. Kaihua Yang et al . revealed that circEIF3K/miR-214/PD-L1 signaling axis was involved in the progression of colorectal cancer. 26 Similarly, circEIF3K was confirmed to be produced by CFAs and delivered to tumor cells via exosomes, indicating a novel ...

Mechanisms Regulating Abnormal Circular RNA Biogenesis in …

WebThe breast cancer cells were used to establish the models in BALB/C nude mice and hypoxia exosomes with circHIF1A shRNA or the controls were injected into the nude … WebAug 1, 2024 · In addition, circHIF1A (circ_0032138) was upregulated in the exosomes, derived from hypoxic Carcinoma-Associated Fibroblasts (CAFs) with time-dependent manner, however it was not influenced by HIF ... opal road home

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WebMay 10, 2024 · So, circHIF1A could be a novel biomarker for the diagnosis and therapeutic target of TNBC . Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. WebTong Chen et al. (2024) revealed that circHIF1A, which was upregulated in the plasma of BC patients, could be selectively loaded into exosomes secreted by BC cells. CircHIF1A promoted TNBC growth and metastasis by regulating NFIB expression and subcellular location and was involved in the circHIF1A/NFIB/FUS positive feedback loop. opal robertson obituary

Identification and characteristics of circHIF1A in breast cancer …

Hypoxia-Induced circRNAs in Human Diseases: From Mechanisms …

WebJul 15, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In … WebJun 12, 2024 · Europe PMC is an archive of life sciences journal literature. opal ritchieWebMini-Circuits. Manufacturer Product Number. PHA-1+. Description. IC RF AMP CATV 50MHZ-6GHZ SOT89. Manufacturer Standard Lead Time. 10 Weeks. Detailed … opal ritchie therapy

"First, we constructed a circHIF1A overexpression plasmid and designed two small interfering RNAs (siRNAs) targeting the splicing junction of circHIF1A. CircHIF1A overexpression and knockdown efficiencies in TNBC were validated by qRT-PCR (Supplementary Fig. 2A). The expression levels of linear HIF1A … See more Fused in sarcoma (FUS) belongs to the FET family of ubiquitously expressed RNA-binding proteins involved in multiple stages of RNA processing [30, 31]. Recently, FUS was … See more Interestingly, we found that ectopic expression of NFIB could increase circHIF1A expression, while NFIB knockdown led to … See more Because the potential roles of FUS in TNBC progression are largely unknown, we conducted functional experiments with FUS overexpression … See more " - Circhif1a

Circhif1a

Frontiers Emerging Role of Cancer-Associated Fibroblasts …

WebK The relative RNA levels of circHIF1A and linear HIF1A were analyzed by qRT-PCR assay after treatment with Actinomycin D in MDA-MB-231 cells. L The relative RNA levels of circHIF1A, linear HIF1A ... WebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 …

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WebMoreover, circHIF1A could be packaged into exosomes and was upregulated in the plasma of breast cancer patients. Our findings indicated that circHIF1A played a critical role in the growth and metastasis of TNBC via a positive feedback loop and that circHIF1A could be a promising biomarker for breast cancer diagnosis and a potential therapeutic ... WebRegulation of HIF-1α stability can also be mediated by an oxygen-independent pathway. In the cytoplasm, HIF-1α is bound to heat-shock protein 90 (Hsp90), leading to enhanced …

WebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … WebcircHIF1A was selectively upregulated in hypoxic breast cancer exosomes specifically.25 Additionally, circHIF1A counteracting miR-580-5p-mediated inhibition on CD44 via sponging miR-580-5p was found to be the mechanism via which CAFs modulated the stemness of cancer cells. The discovery may establish circHIF1A

WebJun 12, 2024 · CircHIF1A may act as a target molecule of breast cancer therapy. Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast … WebJun 3, 2024 · Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications ar ...

WebAug 20, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . Go to: 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In ...

WebAug 29, 2024 · We previously reported that circHIF1A could facilitate TNBC proliferation and metastasis by increasing the expression level of NFIB . However, the functions and underlying mechanisms of circRNAs in regulating chemoresistance of TNBC are largely unknown. Therefore, identifying circRNAs that possess regulatory roles in … opal ring with black bandWebJan 11, 2024 · In support of circHIF1A as a biomarker and target molecule for breast cancer therapy, Zhan and colleagues identified this molecule in a screening of circRNA present in exosomes from hypoxic CAFs in breast cancer . circHIF1A from hypoxic CAFs-derived exosomes proved to be an important player in conferring stem cell properties to breast … iowa employer tax withholding tablesWebJul 28, 2024 · In another study, exosomal circHIF1A significantly promoted triple negative breast cancer growth. An exosomal circHIF1A/NFIB/FUS feedback loop was validated by Chen et al., as exosomal circHIF1A modulated the expression and translocation of NFIB through post-transcriptional and post-translational modification. opal ring in yellow goldWebMar 2, 2024 · CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation 13 March 2024 Tong Chen, Xiaolong Wang, … opal ring white goldWebChen, T., Wang, X., Li, C., Zhang, H., Liu, Y., Han, D., … Yang, Q. (2024). CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by ... iowaemploymentconference.comWebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. opal rooflightWebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … opal rock tumbler