WebDec 13, 2024 · BAT is a safe therapy that resulted in responses in asymptomatic men with metastatic castration-resistant prostate cancer and also resensitisation to enzalutamide in most patients undergoing rechallenge. Further studies with BAT are needed to define the … WebApr 11, 2024 · Based on these studies, we developed a counterintuitive treatment called bipolar androgen therapy (BAT) for patients with CRPC, in which SPA is administered intermittently to result in cycling of serum testosterone from the polar extremes of …
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WebBipolar androgen therapy (BAT) is a paradoxical treatment for castrate-resistant prostate cancer whereby testosterone levels are rapidly alternated between supraphysiologic and near-castrate concentrations. Initial studies demonstrated that BAT is safe and produces clinical responses. A trial comparing enzalutamide against BAT is ongoing. WebFeb 22, 2024 · Bipolar androgen therapy (BAT), defined as rapid cycling between high and low serum testosterone, disrupts this adaptive regulation in castration-resistant PCa (CRPC). METHODS The TRANSFORMER (Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates Enzalutamide Resistance) study … bl64blender shows no power
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WebSince Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR) signaling by reducing AR ligands, it was also … WebOct 24, 2024 · Bipolar androgen therapy resulted in similar progression-free survival and reduction in prostate-specific antigen compared with ... The phase 2 TRANSFORMER study randomly assigned 195 patients with asymptomatic metastatic CRPC to receive monthly BAT as testosterone cypionate or enzalutamide. The primary endpoint was PFS and … WebRe: Effect of Bipolar Androgen Therapy for Asympto-matic Men with Castration-resistant Prostate Cancer: Results from a Pilot Clinical Study Schweizer MT, Antonarakis ES, Wang H, et al Sci Transl Med 2015;7;269ra2 Experts’ summary: Schweizer et al recently conducted a pilot clinical study evalu- bl646 leaf chain